St. Nicholas Byzantine Catholic Church, also known as St. Nicholas Greek Catholic Church, is a historic Catholic Church church at 504 S. Liberty Street in Perryopolis, Fayette County, Pennsylvania. It was built between 1912 and 1918, and is a 30 feet by 60 feet yellow brick building in the Byzantine Revival style. It has a cruciform plan and the gabled roof is topped by four onion domes. The church served a community of Rusyns who originally settled in the area prior to 1907.